The Role of Hepatic Vagal Tone in Ozone-induced Metabolic...

us-epa-gov·January 21, 2025

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The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver

Summary

Original Title: The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver

Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available. This dataset is associated with the following publication: Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021).

Source: https://catalog.data.gov/dataset/the-role-of-hepatic-vagal-tone-in-ozone-induced-metabolic-dysfunction-in-the-liver
Last updated at https://catalog.data.gov/organization/epa-gov : 2022-07-15
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CreatedJuly 20, 2022
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The Role of Hepatic Vagal Tone in Ozone-induced Metabolic...

us-epa-gov·January 21, 2025

Description

The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver

Summary

Original Title: The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver

Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available. This dataset is associated with the following publication: Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021).

Source: https://catalog.data.gov/dataset/the-role-of-hepatic-vagal-tone-in-ozone-induced-metabolic-dysfunction-in-the-liver
Last updated at https://catalog.data.gov/organization/epa-gov : 2022-07-15
More about U.S. Government Works

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